عنوان المقالة:تخليق وتشخيص ودراسة الفعالية البايولوجية لبعض المركبات الحلقية غير المتجانسة الجديدة من مشتق 4- امينو اسيتوفينون SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME NEW HETEROCYCLIC COMPOUNDS DERIVED FROM 4- AMINOACETOPHENONE
Nadia Sadiq Majeed, Hanan Falah Mohsen and Radhiyah Abdul Baqi
Abstract
Our work aimed for organic synthesis and biological investigation of some new heterocyclic derivatives by three
steps : the first step included synthesis of some five-membered and six-membered heterocyclic derivatives (Pyrazole, Isoxazole,
Oxazine and Thiazine) from Chalcone. The second step included synthesis of some 1,3-Oxazipene derivatives from Schiff’s
bases derived from Azo compound. The third step included the assay of biological activity of all compounds against four types of
pathogens bacteria (Staphylococcus aureus, Granutice tella adiacens) gram positive and ( E. coli, Proteus mirabilis) gram
negative the results exhibited excellent biological activity for all derivatives compared to antibiotics (Ampicillin and Ciprofloxacin).
These compounds were identified and confirmed by FT- IR, 1HNMR, 13CNMR and elemental analysis.
Abstract
Our work aimed for organic synthesis and biological investigation of some new heterocyclic derivatives by three
steps : the first step included synthesis of some five-membered and six-membered heterocyclic derivatives (Pyrazole, Isoxazole,
Oxazine and Thiazine) from Chalcone. The second step included synthesis of some 1,3-Oxazipene derivatives from Schiff’s
bases derived from Azo compound. The third step included the assay of biological activity of all compounds against four types of
pathogens bacteria (Staphylococcus aureus, Granutice tella adiacens) gram positive and ( E. coli, Proteus mirabilis) gram
negative the results exhibited excellent biological activity for all derivatives compared to antibiotics (Ampicillin and Ciprofloxacin).
These compounds were identified and confirmed by FT- IR, 1HNMR, 13CNMR and elemental analysis.
نادية صادق مجيد | Nadia Sadiq Majeed | 4714