Issam A. Latif, Hilal M. Abdullah, Maida Hameed Saleem
Abstract
Magnetic iron oxide nanoparticles (Fe3O4 MNPs) were synthesized by co-precipitation method and coated with electrical conductive hydrogel {polyvinyl alcohol (PVA) solution with chitosan (C) and glutaraldehyde (G) as crosslinking agent}/ polyaniline (CPG/PANI). The coated form (CPG/Fe3O4/PANI) was loaded with indigo carmine dye which used as drug model, the drug release was tested by using UV-Vis Spectrophotometer at different temperatures (35.5, 37, 38.5)°C and different voltages (3, 5, 8) V in phosphate buffer solution (pH=7.4). The uncoated and coated Fe3O4were characterized by FTIR spectra, X-ray diffractions and the average size was found to be about (11-13) nm for uncoated while (12-14) nm for coated form. The surface morphology of coated form (CPG/Fe3O4/PANI) was studied by using scanning electron microscope SEM, energy dispersive X–ray spectroscopy (EDS) besides transmission electron microscope (TEM). The (CPG/Fe3O4/PANI) show the best releasing at 37°C.
مائدة حميد | maida hameed | 2917