عنوان المقالة:دراسة التوافر الحيوي لعقار الامبسيلين لدى المتطوعين العراقيين باستخدام كروماتوغرافيا السائل عالي الاداء Bioavailability of ampicillin 500 mg capsule on healthy Iraqi volunteers by HPLC.
Ahmed Mahdi Saeed, Mohammed Redha Hadi , and Fadhil Muhsin Abid
Abstract
تم دراسة التوافر الحيوي لعقار الامبسيلين عند بعض المتطوعين العراقيين الاصحاء ودراسة حركيات عملية الامتصاص والطرح باستخدام تقنية كروماتوغرافيا السائل عالي الاداء
Abstract
The bioavailability of ampicillin after a single dose (500 mg) orally administrated was investigated in 20 Iraqi healthy volunteers. Serum concentrations of ampicillin were determined at various times after administration by a sensitive and specific High Performance Liquid Chromatography (HPLC). The method is linear with R2 value of (0.9994). Ampicillin was well absorbed rapidly after administration. The mean maximum concentration (Cmax) was found to be 7.14 ± 0.62 μg/mL occurring at maximum time (Tmax) of 1hr. The elimination half-life (T1/2), area under the curve concentration (AUC0-8), absorption rate constant (ka), and elimination rate constant (ke) values were found to be 1.34 ± 0.08 hr, 16.07 ± 0.61 μg. mL-1. hr., 1.72 ± 0.06 hr-1 and 0.52 ± 0.03 hr-1, respectively. The effect of volunteers characteristics on bioavailability ampicillin after administration 500 mg single dose were investigated.
Publication Date
8/4/2017
Publisher
Research Journal of Pharmaceutical, Biological and Chemical Sciences
احمد مهدي سعيد محمد | Ahmed Mahdi Saeed Mohammed | 8530