عنوان المقالة:تطوير طريقة طيفية لتقديرالايبوبروفين والكافائين DEVELOPMENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF IBUPROFEN AND CAFFEINE IN PURE AND TABLET DOSAGE FORMS
تم تطوير طريقة طيفية لتقدير مزيج من الايبوبروفين والكافائين بالمستحضرات الصيدلانية
Abstract
This research involved the development of spectrophotometric method for determination of Ibuprofen (IB), Caffeine (CAF)) in mixture of standard and manufactured tablets without any separation method between the two drugs in the mixture. The process was conducted using deionized water: acetonitrile mixture (90:10 v/v) as solvent. The maximum absorbance of drugs in mixture was found to be at (223 nm and 272 nm) for IB, CAF respectively. These wavelengths were selected for the analysis of drugs as mixtures standard and manufactured samples. The method was linear in the range of (0.3- 30 μg/mL) for (IB, CAF), with an R2 of (0.9994, 0.9992) for IB and CAF respectively in the mixture. Recovery means were found to be (100.72, 100.90) for IB and CAF respectively. The method was applied for the estimation of the active gradient of the drugs in different samples of manufactured dosage. The accuracy of method was validated by mean percentage recovery, which was found to be in the acceptable range.
Publication Date
5/1/2018
Publisher
European Journal of Biomedical AND Pharmaceutical sciences
احمد مهدي سعيد محمد | Ahmed Mahdi Saeed Mohammed | 7228