عنوان المقالة:عامل لوني جديد لتقدير الكلوروبرومازين NEW CHROMOGENIC REAGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF CHLORPROMAZINE HCL IN AQUEOUS SOLUTIONS AND PHARMACEUTICAL FORMULATIONS
MOHAMMED.J.HAMZAH.AL-KAFFIJI* AND AHAMED.M.SAEED.AL-ANBAKEY
Abstract
تم استخدام عامل جديد لتوليد اللون لتقدير عقار الكلوروبرومازين في المحاليل المائية والمستحضرات الصيدلانية
Abstract
Objective: Simple, rapid and accurate spectrophotometric method has been developed for the determination of Chlorpromazine HCl in pure and pharmaceutical formulations.
Method: The method is based on the formation of violet color product as a result to interaction of mentioned drug with P-amino acetanilide as new chromogenic reagent in the presence of ferric chloride hexahydrate. The experiential conditions have been studied by UV-Vis spectrophotometric analysis.
Results: The calibration curve was linear in the range 4-32ppm with a correlation coefficient of 0.9990 with a maximum absorbance at 590nm, while the limit of detection(L.O.D) was1.7ppm. The results compare favorable with those of official methods.
Conclusion: The proposed method is simple and economical and can be used in the estimation of chlorpromazine HCl in bulk and pharmaceutical formulations.
Publication Date
7/5/2013
Publisher
International Journal of Pharmacy and Pharmaceutical Sciences
احمد مهدي سعيد محمد | Ahmed Mahdi Saeed Mohammed | 7432