عنوان المقالة:التأثير السمي الخلوي للمستخلص المائي الخام لنبات عين البزون Vinca rosea في خط خلايا ) L20B) خارج الجسم الحي Cytotoxic Effect of Vinca rosea Aqueous Extracts on (L20B) Cell Line In Vitro
The present study included the cytotoxic effects of aqueous crude extracts of Vinca rosea leaves , flowers and seeds on cell line (L20B Cell line)in vitro , by using double dilution series (concentration between 1.95 – 1000 µg/ ml.
The results showed that the cytotoxic effect of extract is dependent on type of extract, amount of dose and exposure time. The concentration 1000 µg/ml gave higher growth inhibition (IR) (74 and 74%) to leaves and flowers respectively compared with control 100% after 24 hours exposure time, but seeds were (49%) after 48 hours. However, low concentrations of aqueous extracts were found to induce the L20B cells growth and proliferation (PR), which recorded (122, 123) % by treatment with flowers extract in 1.95 µg/ ml after 72 hours. Crude aqueous extract of Vinca rosea had hormetic effect (Hormesis), because it also induced the proliferation of cancer cells by using low concentrations of the extract.
Publication Date
11/18/2019
Publisher
Indian Journal of Public Health Research & Development
هند حسين عبيد | Hind Hussein Obaid | 27557