Alyaa Majid, RanaTalib Al-Muswie and Khalid G Al-Fartosi
Abstract
The present study aimed to investigate the effect of isosorbidedinitrate on lipid profile and oxidant-antioxidant markers of hypercholesterolemia female rats. Twenty four adult female albino rats weighting 170-190 g were divided randomly into four groups (six for each group), as follows: Group (1) : (Control group): Rats were fed on standard diet and supplied with tap water ad libitum for 30 days. Group (2) : (Cholesterol-treated group): Rats were treated with daily high cholesterol diet for 30 days. Group (3): (ISDN-treated group): Rats were administered a daily oral dose of ISDN (1.0 mg/kg BW dissolved in 0.5 ml distill water) for 30 days. Group (4): Rats were daily treated with (1 mg/kg dissolved in 0. 5 ml distill water) of ISDN besides high cholesterol diet for 30 days. Serum total cholesterol, triglycerides, high density lipoprotein, low density lipoprotein, very low density lipoprotein, malondialdehyde, albumin and reduced glutathione were determined. The results showed a significant increase (P≤0.05) in the levels of total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein and malondialdehyde; while there was a significant decrease in the levels of high density lipoprotein, albumin and reduce glutathione in cholesterol treated group in comparison with control group. In addition, ISDN administration caused a significant decrease in the levels of total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein and malondialdehyde, with a significant increase in the levels of high density lipoproten, albumin and reduced glutathionein group(4) in comparison with group(2).
علياء ماجد منادي | Alyaa Majid Munadi | 3789