Background: Diabetes mellitus is a clinical syndrome characterized by hyperglycemia due to absolute or relative deficiency of insulin. Current study was aimed to observe the lipid profile, malondialdehyde, antioxidant and electrolyte levels in type 2 diabetes mellitus patients.
Methods: Serum glucose, total cholesterol, triglycerides, high density lipoprotein, very low density lipoprotein and low density lipoprotein, malondialdehyde (MDA), ceruloplasmin, uric acid, sodium, potassium and chloride levels were determined in 75 patients with type II diabetes mellitus and 25 healthy subjects.
Results: The levels of serum glucose, total cholesterol, triglycerides, very low density lipoprotein, low density lipoprotein, malondialdehyde, ceruloplasmin, sodium, potassium and chloride showed significant increase in ype II diabetes mellitus patients as compared to control group whereas the levels of high density lipoprotein and uric acid showed a significant decrease in type II diabetes mellitus patients in comparison to control subjects ( P ≤0.05 ). In addition, current study demonstrated the characteristic diabetic dyslipidaemia which is characterized by low HDL and high triglyceride. Increased levels of MDA may be a useful marker of oxidative stress. Increased oxidative stress may result in consumption of antioxidants including ceruloplasmin. Also, there is significant decrease in serum uric acid levels in type II diabetes mellitus patients. It may be concluded from this study that dysregulation of glucose homeostasis may lead to electrolytes imbalance due to increase in sodium and potassium chloride levels
علياء ماجد منادي | Alyaa Majid Munadi | 3759