Khalid G. Al-Fartosi, Auhood Kadhim Zaid, Alyaa Majid, Mohammed A. Auda
Abstract
The present study investigated the effect of
alkaloid compound isolated from Hapalosiphon aureus
against paracetamol induced toxicity in male rats. Twenty
four white male rats were used, these animals were divided
into four groups each group contain six animals as a
following: the first group I is the control group treated
ml/kg) of normal saline for two weeks, the second group (II)
treated with (1 ml/kg) of alkaloid compound isolated from
Hapalosiphon aureus for two week, the third group III
treated (I.P.) with paracetamol (1 ml/ kg) at the first day and
fourth day of the first week , the fourth group IV treated
(I.P.) with paracetamol (1 ml/ kg ) at the first day and the
fourth day of the first week , and then treated orally with
Hapalosiphon aureus for one week of the fourth group . The
result indicate that the paracetamol caused a significant
increased (p < 0.05) in the level of the serum alanin
transferase (ALT), aspartate transferase
and triglyceride levels in the third group
control group. Also, there was a significant decreased in
albumin. Protective activity of alkaloid compound isolated
from Hapalosiphon aureus against toxicity of paracetamol
observed in decreasing of ALT, AST,
triglyceride levels, and increased in the albumin levels in the
fourth group comparison with third group
Publication Date
5/26/2014
Publisher
International Journal of Agriculture Innovations and Research
علياء ماجد منادي | Alyaa Majid Munadi | 3983