Khalid G. Al-Fartosi, Alyaa Majid, Mohammed A. Auda and Murtda Hafedh Hussein
Abstract
ABSTRACT
Carbon tetrachloride (CCl4) is a highly toxic chemical agent. Therefore, the present study was carried out to
investigate the protective effects of camel's milk against CCL4 induced oxidative stress in male white albino rats.
White albino male rats (150-200 g) were divided into four groups of 6 rats: a control group fed only with diet and
tap water for two weeks, the second group fed with standard diet and camel milk, the third group intoxicated with
CCl4 on first two days of the experimental 14 days and fed with tap water and diet, and the fourth group
intoxicated with CCl4 on first two days of the experimental 14 days and then treated with camel milk .
Intrapretoneal injection of male rats with CCl4 induced lipid peroxidation in the liver, which was indicated by a
significant increase in lipid peroxidation biomarkers (TBARS). Also the data showed that the treated of male rats
with CCl4 caused a significant increases in the serum levels of iron and ceruloplasmin, while the levels of
transferrin and albumin were decreased significantly in male rats treated with CCl4. In all rats treated with camel’s
milk after given CCl4, oxidant-antioxidant markers were altered compared with male rats treated with CCl4 only.
Publication Date
1/30/2012
Publisher
International Journal of Research in Pharmaceutical and Biomedical Sciences
علياء ماجد منادي | Alyaa Majid Munadi | 3759