عنوان المقالة: Protective role of polyphenolic compounds extracted from cyperus rotundus rhizomes and taurine on troponin-I and some oxidant/antioxidants parameters of female rats treated with isoproterenol – induced myocardial infraction
Mohammed A . Auda, Khalid G . Al-Fartosi, Alyaa Majid
Abstract
The present study was designed to investigate the effects of polyphenolic
compounds extracted from cyperus rotundus rhizomes and taurine on
isoproterenol induced myocardial infraction in female rats. Sixty of
female rats (Rattus norvegicus) were used in the present study. Animals
were divided into 10 groups ( 6 for each group). MI was induced in rats
with ISO (85 mg/kg) twice at an interval of 24 hrs. ISO produced
significant alterations in the troponin-I, serum MDA, tissue MDA, Cp,
Alb, uric acid, serum GSH and tissue GSH. The effect of polyphenolic
compounds from cyperus rotundus rhizomes oral treatment for 21 days at
two doses (15 mg and 30 mg/kg, body weight) and taurine at two doses (
100 mg and 200 mg/kg, body weight) was evaluated against ISO- induced
cardiac necrosis. The results showed a significant increase in the level of
serum troponin-I, serum MDA, tissue MDA, Cp and uric acid in ISOtreated
animals as compared with the control animals. While, the results
showed asignificant decrease in the level of serum Alb, serum GSH and
tissue GSH in ISO- treated animals as compared with the control animals.
Polyphenolic compounds from cyperus rotundus rhizomes and taurine
showed a significant cardioprotective activity by lowering the levels of
serum troponin-I, serum MDA, tissue MDA, Cp and uric acid and elevate
the levels of Alb, serum GSH and tissue GSH. This study concluded that
the polyphenolic compounds from cyperus rotundus rhizomes and taurine
possess cardioprotective activity against Isoproterenol induced
myocardial infraction in rats
علياء ماجد منادي | Alyaa Majid Munadi | 3768