عنوان المقالة:تطوير الطريقة والتحقق من صحتها للتقدير المتزامن لأتورفاستاتين وإيزيتيميب في شكل جرعات صيدلانية بواسطة HPLC Method Development and Validation for Simultaneous Estimation of Atorvastatin and Ezetimibe in Pharmaceutical Dosage Form by HPLC

سعيد مزعل موازي | SAEID MEZAIL MAWAZI | 5535

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Publication Type

Journal

Arabic Authors

سعيد مزعل موازي و سرينيفاس ريدي

English Authors

Saeid Mezail Mawazi & GNVCS Reddy

Abstract

A new HPLC method was developed and validated for the determination of Atorvastatin and Ezetimibe in tablet dosage form. The chromatographic separation was achieved on a Inspire C18(4.6 x 250mm, 5m) with a mobile phase combination of phosphate buffer, methanol and Acetonitrile (40:10:50) at a flow rate of 1.2 ml/min, and the detection was carried out by using UV detector at 233 nm. The total run time was 8minutes.The retention time of phosphate buffer, methanol and Acetonitrile were found to be 2.237 min. and 3.164 min. respectively. The performance of the method was validated according to the present ICH guidelines. - See more at: http://www.wjpsonline.org/view_issue.php?title=Method-Development-and-Validation-for-Simultaneous-Estimation-of-Atorvastatin-and-Ezetimibe-in-Pharmaceutical-Dosage-Form-by-HPLC#sthash.XjmeS9TO.dpuf

Publication Date

1/8/2014

Publisher

ًWorld Journal of Pharmaceutical science

Volume No

2

Issue No

8

Pages

866-870

File Link

تحميل (193 مرات التحميل)

External Link

http://www.wjpsonline.org/view_issue.php?title=Method-Development-and-Validation-for-Simultaneous-Es

Keywords

علاج الكوليستيرول , الكوليستيرول , علاج الدهون الثلاثية , اتروفوستاتين , ايزتيمايب , cholesterol tre