عنوان المقالة:مركبات غير حلقية من الجزء الفعال بيولوجيا من مستخلص أزهار نبات الألبيزيا لبخ "دقن الباشا" New acyclic secondary metabolites from the biologically active fraction of Albizia lebbeck Flowers
Shaza M. Al-Massarania, Ali A. El Gamala,b*, Mohamed Farag, Mansour S. Al-Saida, Maged S. Abdel-Kaderc, Omer A. Basudana, Saleh I. Alqasoumi
Abstract
The total extract of Albizia lebbeck flowers was examined in vivo for its
possible hepatoprotective activity in comparison with the standard drug silymarin at two
doses. The higher dose expressed promising activity especially in reducing the levels of
AST, ALT and bilirubin. Fractionation via liquid- liquid partition and reexamination of
the fractions revealed that the n-butanol fraction was the best in improving liver
biochemical parameters followed by the n-hexane fraction. However, serum lipid
parameters were best improved with CHCl3 fraction. The promising biological activity
results initiated an intensive chromatographic purification of Albizia lebbeck flowers
fractions. Two compounds, identified from natural source for the first time, the acyclic
farnesyl sesquiterpene glycoside1-O-[6-O--L- arabinopyranosyl--D-glucopyranoside]–
(2E,6E-) -farnesol (6) and the squalene derivative2,3-dihydroxy-2,3-dihydrosqualene (9), in
addition to eight compounds reported here for the first time from the genus Albizia; two
benzyl glycosides, benzyl 1-O--D- glucopyranoside (1) and benzyl 6-O--Larabinopyranosyl
-D-glucopyranoside (2); three acyclic monoterpene glycosides, linalyl
- D- glucopyranoside (3) and linalyl 6-O--L-arabinopyranosyl - -D-glucopyranoside
(4); 2E)-3,7-dimethylocta-2,6-dienoate-6-O--L arabinopyranosyl- -D-glucopyranoside
محمد فرج عبد الحليم عبد الله | Mohamed Farag Abd El Halim Abd Alla | 5367