عنوان المقالة:التقييم الكيميائي والمضاد للميكروبات والمضاد للطفيليات لغلاف ثمرة نبات الجارسينيا مانجوستانا و مركبه الرئيسي الفامانجوستين Phytochemical, antimicrobial and antiprotozoal evaluation of Garcenia mangostana pericarp and its major xanthone derivative α-mangostin
Shaza M. Al-Massarani 1, Ali A. El Gamal 1,2,*, Nawal M. Al-Musayeib 1, Ramzi A. Mothana 1, Omer A. Basudan 1, Adnan J. Al-Rehaily 1, Mohamed Farag 1, Mahmoud H. Assaf 3, KamalEldin H. El Tahir 4 and Louis Maes
Abstract
Five xanthone derivatives and one flavanol were isolated from the
dichloromethane extract of Garcinia mangostana. Dichloromethane, ethyl acetate extract
and the major xanthone (α-mangostin) were evaluated in vitro against erythrocytic
schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and
Trypanosoma cruzi and free trypomastigotes of T. brucei. The major constituent
α-mangostin was also checked for antimicrobial potential against Candida albicans,
Escherichia coli, Pseudomonas aeruginosa, Bacillius subtilis, Staphylococcus aureus,
Mycobacterium smegmatis, M. cheleneoi, M. xenopi and M. intracellulare.
محمد فرج عبد الحليم عبد الله | Mohamed Farag Abd El Halim Abd Alla | 5367