عنوان المقالة:ألباكتام- مركب جديد من أزهار نبات الألبيزيا لبخ - وتأثيره المضاد للتخثر خارجيا A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro
Ali Ali El Gamal1,2*, Mohamed Farag Abd El Halim1, Ashraf Taha Kalil1,2, Omer Ahmed Basudan1, Adnan Jathlan Al-Rehaily1, Mohamed Shamim Ahmad1, Kamal Hussin El Tahir3, Shaza Mohamed Al-Massarani1 and Wael Moustafa Abdel-Mageed1
Abstract
A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia
lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced
guinea-pigs’ platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by
measuring 1D and 2D NMR, two of them are the triterpenes β- amyrin and 11α, 12α-oxidotaraxerol, two ceramide
derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.
محمد فرج عبد الحليم عبد الله | Mohamed Farag Abd El Halim Abd Alla | 5367