عنوان المقالة:Comparative study of the molecular, biochemical, and other parameters in Iraqi hepatitis B patients Comparative study of the molecular, biochemical, and other parameters in Iraqi hepatitis B patients
Ban M. A. Al-Kanaan1 , Mushtak T. S. Al-Ouqaili2 *, Khalid F. A. Al-Rawi3
Abstract
Background/Purpose: It well recognizes that hepatitis B infections are one of the most medically important problematic
infections in the world. We compared the molecular, biochemical, and other parameters of two study groups of hepatitis B
patients depending on the result of hepatitis B e antigen (HBeAg). Methodology: The serological indicators of 80 study
patients with chronic hepatitis B (CHB) were investigated. The hepatitis B surface antigen (HBsAg) levels were quantified,
and the hepatitis B virus (HBV) viral quantity was determined using a quantitative polymerase chain reaction. The biochemical
and hematological essays of the patients, in addition to 40 healthy individuals, were also detected. Results: HBsAg was
revealed positive in all study patients. They were quantitatively and statistically more significant in those patients positive
for HBsAg than negative ones with a mean of 7779.9 ± 3898 IU/mL and 3233.8 ± 2474 IU/mL, respectively. The HBV-DNA
viral quantity was also much higher in HBeAg-positive patients (35,328,825 ± 23,101,537 IU/mL) than in HBeAg-negative
patients (3115.1 ± 1916.8 IU/mL). Glutamic pyruvic transaminase and glutamic oxaloacetic transaminase values were
elevated in patients carrying HBeAg in comparison with other ones in contrast with gamma-glutamyl transferase (GGT), who
decreased markedly. The level of prothrombin times for HBeAg-positive (15.24 ± 2.0 s) and HBeAg-negative (15.73 ± 2.4 s)
patients was higher than that for the healthy individuals (13.65 ± 0.5 s). Conclusion: The interesting finding that emerged
from this study is the reasonably substantial significant difference between both study groups of HBeAg in terms of HBsAg
level and HBV-DNA load creating an impression that a high level of attention must be brought on the diagnosis and monitoring
of treatment of HBeAg positive patients. Furthermore, several biochemical parameters (aspartate aminotransferase, alanine
aminotransferase, and alkaline phosphatase) were markedly increased in patients who have HBeAg in comparison with those
negative for the presence and controls. In both groups of patients with CHB infections, the GGT levels were observable,
increasing than those in the healthy subjects.
الأستاذ الدكتور مشتاق طالب صالح الندا | Dr. Mushtak T. S. Al-Neda | 8272