ناهوكو أيدا - أحمد سعد أحمد حسانين - ناوكو اينوي - يوشيهيسا أوينوياما - هيروكو تسوكامورا
English Authors
Nahoko Ieda; Ahmed Hassaneen; Naoko Inoue; Yoshihisa Uenoyama; Hiroko Tsukamura
Abstract
The discovery of the role of kisspeptin neurons in the regulation of mammalian reproduction
in 2003 was one of the biggest breakthroughs in reproductive endocrinology within the last few
decades. Research during the past two decades since the discovery of kisspeptin has been
unveiling the mechanism of how the hypothalamic kisspeptin neurons control reproductive
functions through regulation of gonadotropin-releasing hormone (GnRH) secretion. This article
aims to overview kisspeptin research, including the most recent studies from ours and other
research groups, and to discuss the possibility of new strategies to control reproductive functions
in mammals. In the first section, we introduce the critical role of kisspeptin neurons in puberty
onset and reproductive functions in mammals, including the regulation of two modes of
GnRH/gonadotropin secretion, namely pulsatile and surge modes. The next section focuses more
on the mechanism of how the kisspeptin neurons in the arcuate nucleus in the hypothalamus
precisely controls GnRH pulse using other two neuropeptides, neurokinin B and dynorphin A.
The article also discusses the mechanism suppressing reproductive function during lactation and
other stress conditions through inhibition of kisspeptin neurons and consequent
GnRH/gonadotropin secretion, to provide insights on the possibility of new strategies to improve
reproductive performance in mammals including domestic farm animals.
أحمد سعد أحمد حسانين | Ahmed Saad Ahmed Hassaneen | 6069