عنوان المقالة:مضادات الفطريات من جذور و جذيمرات شرش الزلوع Antiungal compounds from the rhizome and roots of Ferula hermonis
عبدالهادي محمد عبدالهادي الجعفري | Abdel Hadi M. Al Jafari | 4244
Publication Type
ScientificArticle
Arabic Authors
عبدالهادي الجعفري. روسر فيلا. بلنكا فريشر. فيلكس تومي. جوزيف كازانوفا. جوان كوستا. سلفادور كانيجرال
English Authors
Abdel-Hadi Al-Ja’fari, Roser Vila, Blanca Freixa, Felix Tomi, Joseph Casanova, Joan Costa, Salvador Cañigueral
Abstract
The antifungal activity of hexane, dichloromethane, methanol and aqueous extracts from the rhizome and root of Ferula hermonis was assayed in vitro by the agar disk diffusion method against a panel of human opportunistic and pathogenic fungi. Among them, the hexane and dichloromethane extracts showed the highest activity particularly against the dermatophytes Microsporum gypseum and Tricophyton mentagrophytes as well as the yeast Candida lactis-condensi. Activity-guided fractionation of both extracts using an agar overlay bioautographic method led to the isolation of two antifungal compounds which were identified as the daucane aryl esters jaeschkeanadiol p-hydroxybenzoate (ferutinin) and jaeschkeanadiol benzoate (teferidin). Determination of minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) values of both compounds evidenced a stronger antifungal activity for ferutinin than for teferidin. Particularly, T. mentagrophytes was the most sensitive strain with MIC and MFC values ranging from 8 to 256 mg/mL.
Publication Date
8/23/2012
Publisher
PHYTOTHERAPY RESEARCH
Volume No
27
Issue No
DOI
10.1002/ptr.4806
Pages
911-915
Keywords
Ferula hermonis; jaeschkeanadiol p-hydroxybenzoate; jaeschkeanadiol benzoate; antifungal activity; dermatophytes.
رجوع