عنوان المقالة:المواد الفعالة في الزيوت الطيارة من جذور و جذيمرات شرش الزلوع Composition and antifungal activity of the essential oil from the rhizome and roots of Ferula hermonis
Abdel-Hadi Al-Ja’fari a,c, Roser Vila a, Blanca Freixa a, Felix Tomi b, Joseph Casanova b, Joan Costa c, Salvador Cañigueral
Abstract
The analysis of the essential oil from rhizome and roots of Ferula hermonis Boiss. (Apiaceae) by GC–FID,
GC–MS and 13C NMR allowed the identification of 79 constituents, more than 90% of the oil, the major one
being a-pinene (43.3%), followed by a-bisabolol (11.1%) and the unusual acetylenic compound 3,5-nonadiyne
(4.4%).
The antifungal activity of the essential oil before and after fractionation was assayed against several
yeasts and filamentous fungi. Purification of the active fractions afforded 3,5-nonadiyne, a-bisabolol,
jaeschkeanadiol angelate, a-bisabolol oxide B and trans-verbenol, as well as two purified fractions, one
of them (JB73) with 73% of jaeschkeanadiol benzoate and the other with 50% of spathulenol. Determination
of MIC and MFC values of all these products evidenced strong antifungal activities for JB73 and
3,5-nonadiyne. Particularly, against the dermatophyte Tricophyton mentagrophytes, MIC and MFC values
were 0.25 lg/ml for JB73, and 8 lg/ml for 3,5-nonadiyne, the former being more active than amphotericin
B and nystatin.
عبدالهادي محمد عبدالهادي الجعفري | Abdel Hadi M. Al Jafari | 4244