Amal Amin, Moshera Samy, Sameh Hosam Abd El-Alim, Abd El Gawad Rabia & Magdy M. H. Ayoub
Abstract
Vitamin C (Vit.C)-entrapped polycaprolactone (PCL) nanoparticles (Vit.C–PCNs) were prepared by
encapsulation of Vit.C into PCL-based nanoparticles (PCNs) which were prepared using double emulsion
method with two steps. First, the inner aqueous phase (W1) was added to dichloromethane solution
containing PCL with homogenization to form primary emulsion (W1/O) which was emulsified with the
outer aqueous phase (W2) containing polyvinyl alcohol as stabilizer to attain the double emulsion (W1/O/
W2). Versatile parameters were investigated to reach to the most successful formulation for Vit.C–PCNs,
such as time, effect of speed of homogenization on drug encapsulation efficiency, etc.
Publication Date
2/7/2018
Publisher
International Journal of Polymeric Materials and Polymeric Biomaterials
د.مشيره سامى عبد العزيز يوسف | Dr.Moshera Samy Abdelaziz Youssef | 2868