عنوان المقالة:التغيرات النسيجية المرضية والكيميائية النسيجية لقرحة المعدة التي يسببها حمض الخليك في الجرذان.... The histopathological and histochemical alterations of the gastric ulcer induced by acetic acid in rats.
عيدة مفتاح عبدالكريم الشيلابي وهناء محمد اسرافيل و أحمد سعيد أحميدة
English Authors
Eda M. A. Alshailabi, Hana M. Asrafiel and Ahmed S. H. Ahmeedah.
Abstract
لا يوجد
Abstract
The pathophysiology of gastric ulcer has centered on an imbalance between aggressive and protective factors in the stomach. The aim of this study was to evaluate the histopathological and histochemical changes in the rat's gastric ulcer induced by acetic acid (AA). For this purpose, thirty albino female rats were divided into three groups, each group carried ten rats. Group I was given distilled water for 14 days and served as the control group, while group II was given 1 ml/ kg/ day (5 %) of AA and group III was given 1 ml/ kg/ day (10 %) of AA orally by gavage for 14 days. Results showed the appearance of some histopathological changes including exfoliated dead cells appear in the lumen in the stomach, deeper ulceration with the onset of necrosis and focal necrosis of epithelium with the disrupted cell membrane in AA-5 %. Furthermore, the AA-10 % showed dilatation of the glandular lumina and hemorrhagic lesions in the mucosa of the glandular stomach with the aggregation of inflammatory cells near the bases of the gastric pit and the muscular mucosa. Although the histochemical studies with PAS-reaction and bromophenol blue technique showed a decrease in the carbohydrate and protein content in treated rats. In conclusion, this study showed that acetic acid was a harmful agent associated with histopathological changes that caused acute gastric lesions and ulcers.
د. عيدة مفتاح عبدالكريم الشيلابي | Dr. Eda M. A. Alshailabi | 5209