Waleed Abdelmaguid 1,2 , Doha Maher 3, Mohamed A. S. Kohla 1,4, Sameera Ezzat 1,5,†, Inas Moaz 5, Wael S. Abdel-Mageed 6, Khalil A. El-Halfawy 2 and Mohamed H. Abdel-Rahman 1,3,7,*
Abstract
Simple Summary: Egypt has the highest prevalence of hepatitis C infection in the world with a dramatic increase in the incidence of hepatocellular carcinoma (HCC) observed during the last decade. Currently, HCC is the most prevalent cancer in men and the second most prevalent cancer in women in Egypt. There are limited published data on the implication of host KIR genotypes and the progression of chronic hepatitis C virus (HCV) infection to HCC. We describe the first analysis of Egyptian KIR genotypes from the Nile Delta region. The findings of this study suggest that KIR haplotype AA, that contains dominantly inhibitory genes, was less frequent in HCC patients compared to chronic HCV patients and healthy control subjects. Therefore, haplotype AA may have a crucial role in host defense against HCC progression.