عنوان المقالة:التأثيرات الوقائية للإندول -3 كاربينول على إصابة المعدة في الجرذان. The Protective Effects of Indole-3-carbinol on Stomach Injury in Rats.
ا.د. عيدة مفتاح عبدالكريم الشيلابي | Prof. Dr. Eda M. A. Alshailabi | 6109
- نوع النشر
- مجلة علمية
- المؤلفون بالعربي
- عيدة مفتاح عبدالكريم الشيلابي
- المؤلفون بالإنجليزي
- Eda M. A. Alshailabi.
- الملخص العربي
- لا يوجد
- الملخص الانجليزي
- The objective of this research was to analyze the protective effect of indole-3-carbinol against the stomach injury induced by acetylsalicylic acid. Male rats were randomly divided into eight groups of six animals in each group. Control group, OMP group, I3C group, OMP+I3C group, AA group, AA+OMP group, AA+I3C group, and AA+OMP+I3C group. The control rats were received distilled water and the experimental rats were received AA at a dose of 500 mg/kg body weight, OMP at a dose of 20 mg/kg body weight, and I3C at a dose of 50 mg/kg body weight either alone or in combination with each other, orally for seven consecutive days. Results of the present study showed ulcer protection in indole-3-cabinol treated rats was confirmed by histoarchitecture, which was comprised of the reduced size of ulcer crater and restoration of mucosal epithelium. Thus, reduced neutrophil infiltration, antiapoptotic and antioxidant action have a pivotal role in the gastroprotective effect of indole-3-carbinol.
- تاريخ النشر
- 12/08/2021
- الناشر
- Libyan Journal Of Basic Sciences
- رقم المجلد
- 14
- رقم العدد
- 1
- ISSN/ISBN
- 6261-2707
- رابط DOI
- لا يوجد
- الصفحات
- 12-24
- رابط الملف
- تحميل (0 مرات التحميل)
- رابط خارجي
- https://ljbs.omu.edu.ly/download/the-protective-effects-of-indole-3-carbinol-on-stomach-injury-in-rats/
- الكلمات المفتاحية
- Histopathological, Stomach, Acetylsalicylic acid, Indole-3-carbinol, rats.