عنوان المقالة: Synthesis, Spectroscopic, Thermal Studies of Nickel(II) and Palladium(II) Complexes of Tridentate Ligand and Their DNA Cleavage Activity
أ.د. عبدالسلام معتوق هميل | Prof. Dr. Abdusalam Matoog Hamil | 6279
- نوع النشر
- مجلة علمية
- المؤلفون بالعربي
- المؤلفون بالإنجليزي
- Amna Qasem Ali, Abdusalam Matoog Hamil, Siang Guan Teoh
- الملخص الانجليزي
- Abstract: Two novel complexes of Ni(II) and Pd(II) with Schiff base ligand derived from 5-chloro isatin with 4-phenyl-3-thiosemicarbazid have been synthesized in absolute EtOH. The structures of the isolated solid compounds have been characterized by elemental analyses and spectral (FT-IR and UV-vis.) measurements. The Schiff base ligand was further characterized by mass spectra. All the synthesized compounds were tested against supercoiled pBR322 DNA. It has been found that, the Schiff base ligand behaves as trientate ligand forming chelates with 1:2 (metal:ligand) in case of Ni-complex and 1:1 (metal:ligand) in case of Pd-complex. Octahedral geometry was suggested for the Ni(II) chelate while square-planar geometry was suggested for the Pd(II) chelate. These compounds have been found to promote the cleavage of plasmid DNA pBR322 in the presence of H2O2.
- تاريخ النشر
- 31/03/2016
- الناشر
- مجلة العلوم البحثة والتطبيقية Journal of Pure & Applied Sciences
- رقم المجلد
- 15
- رقم العدد
- 2
- الصفحات
- 36-53
- رابط الملف
- تحميل (53 مرات التحميل)
- الكلمات المفتاحية
- Keywords: 5-chloro isatin; 4-phenyl-3-thiosemicarbazid; trientate ligand; supercoiled pBR322