عنوان المقالة: Effect of hepatoprotective of aqueous extract of Ganoderma lucidum against ketoprofen-induced damage in male rats.
ا.د. عيدة مفتاح عبدالكريم الشيلابي | Prof. Dr. Eda M. A. Alshailabi | 6106
نوع النشر
مجلة علمية
المؤلفون بالعربي
المؤلفون بالإنجليزي
Eda M. A. Alshailabi and Heba M. Suleiman
الملخص الانجليزي
This study's objective was to assess the protective impact of an aqueous extract of G. lucidum against ketoprofen-induced liver damage in male albino rats. Twenty-eight healthy adult male albino rats were divided into four groups (7 rats in each). Group 1: normal control group; Group 2: rats were given ketoprofen (50mg/kg body weight) daily for two weeks, Group 3: rats were given G. lucidum (300mg/kg body weight) daily for four weeks, and Group 4: rats were given ketoprofen (50mg/kg body weight) daily for two weeks, then were given G. lucidum (300mg/kg body weight) daily for four weeks. The histological result of the liver of rats treated by ketoprofen showed degenerating hepatocytes, widened with congested central vein with inflammatory cell infiltration, necrotic areas, widened with congested portal vein, thickening wall of central vein enclosed by fibrotic area, and sever haemorrhage. Whereas, the rats which treated by therapeutic dosages showed improved of hepatic architecture with hepatocytes structures, normal sinusoids, minimal congested central vein, improved in the portal area with few inflammatory cell infiltrations, normal sinusoids, and minimal congested portal vein. In conclusion, this study shows that the G. lucidum has protective effects against ketoprofen induced hepatic injury in adult male albino rats.
تاريخ النشر
01/07/2024
الناشر
The International Innovations Journal of Applied Science
رقم المجلد
1
رقم العدد
2
ISSN/ISBN
3009-1853
الصفحات
1-6
رابط الملف
تحميل (0 مرات التحميل)
رابط خارجي
https://iijas.eventsgate.org/iijas
الكلمات المفتاحية
ketoprofen Ganoderma lucidum Liver Histopathology Rats
رجوع