Development of a Simple Colorimetric Determination of Dexamethasone

أ.د. علي خليل محمود | Prof. Dr. Ali Khalil Mahmood

16/10/2020 القراءات: 2236  

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Development of a Simple Colorimetric Determination of Dexamethasone
International Journal of Drug Delivery Technology, Volume 10, Issue 2, 2020
خالد وليد صالح، علي خليل محمود ، حسن محمد لعيبي
Khalid Waleed S. Al-Janabi1, Ali Khalil Mahmood , Hasan M. Luaibi
A simple, environmentally benign, cost-effective, and sensitive colorimetric determination for the pharmaceutical drug dexamethasone sodium phosphate (DXP) has been developed by the formation of a colored complex with fluoranil. The process was sensitive and linear over the range 1 to 40 μg/mL, excellent correlation coefficient 0.9989, recovery% 99.80 ± 1.3, limit of detection (LOD) and limit of quantification (LOQ) were 0.23 and 0.9 μg/mL, respectively, and good RSD ~1.63%. The experimental conditions were optimized after an intensive study. The approach was validated statistically for the quantification of the analyte in its pure and/or pharmaceutical form. Despite the proposed approach is selective, it still can be applied for the analysis of other pharmaceuticals.

Colorimetry Dexamethasone

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