عنوان المقالة:Ahmed, R.G., M. Abdel-Latif, Ahmed F., 2015. Protective effects of GM-CSF in Experimental Neonatal Hypothyroidism. International Immunopharmacology 29, 538–543.
Hypothyroidisminduced bymethimazole (MMI), has a negative impact on the postnatal development. Neonatal
GranulocyteMacrophage-Colony Stimulating Factor [GM-CSF; 50 μg/kg, intramuscular injection at postnatal day
(PND) 17] had been tested to ameliorate the effects ofMMI [0.05%, (weight per volume; w/v), intraperitoneal injection
at PND 15]-induced hypothyroidisminWistar rats. The hypothyroid conditions due to the administration
of MMI produced inhibitory effects on neonatal serum thyroxine (T4), 3,5,3′-triiodothyronine (T3), neutrophil
count in bone marrow and blood, cerebellar glutathione (GSH) and acetylcholinesterase (AchE), although it
induced stimulatory actions on serum thyrotropin (TSH), growth hormone (GH), insulin growth factor-II (IGFII),
tumor necrosis factor alpha (TNF-α), and cerebellar malondialdehyde (MDA) at PND 19. The treatment
with GM-CSF could reverse the depressing and stimulating effects ofMMI on these markers except for cerebellar
AchE where its enhancement was non-significant (P N 0.05) at tested PND. Thus, neonatal GM-CSF may be responsible
for suppressing autoimmune responses and preventing hypothyroidism.
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