عنوان المقالة: Synthesis, Spectroscopic, Thermal Studies of Nickel(II) and Palladium(II) Complexes of Tridentate Ligand and Their DNA Cleavage Activity
Abstract: Two novel complexes of Ni(II) and Pd(II) with Schiff base ligand derived from
5-chloro isatin with 4-phenyl-3-thiosemicarbazid have been synthesized in absolute EtOH.
The structures of the isolated solid compounds have been characterized by elemental analyses
and spectral (FT-IR and UV-vis.) measurements. The Schiff base ligand was further
characterized by mass spectra. All the synthesized compounds were tested against supercoiled
pBR322 DNA. It has been found that, the Schiff base ligand behaves as trientate ligand
forming chelates with 1:2 (metal:ligand) in case of Ni-complex and 1:1 (metal:ligand) in case
of Pd-complex. Octahedral geometry was suggested for the Ni(II) chelate while square-planar
geometry was suggested for the Pd(II) chelate. These compounds have been found to promote
the cleavage of plasmid DNA pBR322 in the presence of H2O2.
Publication Date
3/31/2016
Publisher
مجلة العلوم البحثة والتطبيقية Journal of Pure & Applied Sciences
أ.د. عبدالسلام معتوق هميل | Prof. Dr. Abdusalam Matoog Hamil | 6217