There is evidence that interventions based on practicing gratitude may enhance subjective well-being. This study investigated the effect of a gratitude intervention on psychological well-being among a sample of females breast cancer patients in Saudi Arabia Kingdom (N=60). Researchers applied a scale of psychological well-being (PWB) and a scale of gratitude and the counselling program based on gratitude. Participants were measured at three points in time: before the intervention, immediately after the termination of intervention (week 4), and at follow-up after one month. The results revealed that the gratitude intervention enhanced psychological well-being in participants, and this positive effect of practicing gratitude on psychological well-being persisted over one month. Theoretical and practical implications of these findings are discussed.